Human Chorionic Gonadotropin

Human Chorionic Gonadotropin (hCG)

Human Chorionic Gonadotropin (HCG) is a hormone that is naturally produced in the placenta during pregnancy. While its primary role is to support the development of the fetus, HCG has also been used in various medical contexts, including in the treatment of certain fertility issues in both men and women.

In men, HCG can be administered to stimulate the production of testosterone and enhance fertility. Here are some ways in which HCG may help men:

  1. Stimulates Testosterone Production
  2. Preserves Fertility
  3. Maintains Testicular Size
  4. Hormone Balance

The Booster

Use hCG as an add-on to your current testosterone therapy for better results, or use it on its own for a natural increase to your testosterone production.

hCG therapy is 80 to 100 percent covered by private insurance plans. Pay and submit pharmacy receipt for reimbursement

*Your information is secured and encrypted at-rest and in-transit.
*You will only be charged for the applicable doctor consult and fees. The medication will not be charged until the doctor has deemed that the treatment is applicable to you
*To start the process for testosterone replacement therapy, payment must be completed for all doctor consults, lab requisition fees and service fees

How is human chorionic gonadotropin beneficial for men?

Human Chorionic Gonadotropin (HCG) is not typically used specifically for muscle building in men. HCG is a hormone that mimics the action of luteinizing hormone (LH) and is primarily involved in the stimulation of the testes to produce testosterone. Testosterone is a key hormone for the development and maintenance of male reproductive tissues, as well as for the regulation of muscle mass, bone density, and overall body composition.

Important Safety Information

What Sildenafil does:

SILDENAFIL belongs to a class of medicine called phosphodiesterase type 5 (PDE5) inhibitors. Following sexual stimulation, SILDENAFIL works by helping to relax the blood vessels in your penis by allowing blood to flow into your penis. This results in improved erectile function.

When Sildenafil should not be used:

  • If you are taking any medicines containing nitrates in any form (oral, sublingual [under the tongue], skin patch, or by inhalation [spray]). Although SILDENAFIL is used occasionally, nitrates must never be used. Nitrates are found in many prescription medicines that are used in the treatment of angina pectoris (chest pain due to heart disease), such as nitroglycerin, isosorbide mononitrate, or isosorbide dinitrate. If you do not understand what nitrates are, or are unsure about whether a medication you are taking is a “nitrate”, ask your doctor or pharmacist.

If you take SILDENAFIL with nitrate containing medicines or any other nitrates (e.g., amyl nitrite “poppers”), your blood pressure could suddenly drop to a life-threatening level. You could get dizzy, faint, or even have a heart attack or stroke.

  • If you have ever had an allergic reaction to sildenafil citrate or the nonmedicinal ingredients in SILDENAFIL.
  • SILDENAFIL is not to be used in men for whom sexual activity is inadvisable.

This medicine has been prescribed for you personally and you should not pass it on to others. It may harm them, even if their symptoms are the same as yours.

BEFORE you use SILDENAFIL talk to your doctor or pharmacist if you:

  • have heart problems (irregular heartbeats, angina, chest pain or had a heart attack). If you have heart problems, ask your doctor if your heart is healthy enough to handle the extra strain of having sex. If you have chest pain, dizziness or nausea during sex, stop exerting yourself. You should not use nitrates, but you should seek immediate medical assistance.
  • are 65 years of age or over
  • have had a stroke
  • have low blood pressure or uncontrolled high blood pressure
  • have liver or kidney problems
  • have sickle cell anemia (abnormality of the red blood cells), multiple myeloma (cancer of the bone marrow) or leukemia (cancer of the white blood cells)
  • are allergic to sildenafil or any of the other ingredients of SILDENAFIL tablets
  • have a deformed penis or Peyronie’s disease
  • have ever had an erection that lasted more than 4 hours
  • have stomach ulcers or other bleeding problems.
  • have a rare inherited eye disease called retinitis pigmentosa
  • Ever had temporary, decrease, or permanent loss of vision, including a condition called Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION). The specific type of vision decrease or loss, called non-arteritic anterior ischemic optic neuropathy (NAION), seems to occur rarely when blood flow to the optic nerve is reduced or blocked. Vision decrease or loss may be partial or complete, in one or very occasionally both eyes. While in some cases the condition may improve over time, it can also be irreversible. Rare cases of central serous chorioretinopathy (serous detachment of the macula layers of the retina) have been reported.
  • Rare but serious skin reactions of Stevens-Johnson’s Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) have been reported during the post-marketing period.

SILDENAFIL is not recommended for use in children under 18 years of age and in women.

SILDENAFIL does not protect against sexually transmitted diseases (STD), including Human Immunodeficiency Virus (HIV).

Alcohol consumption may decrease the ability to get an erection. Patients should know how to react to the drug before operating a motor vehicle or any machinery. If you are taking SILDENAFIL and experience temporary, decrease, or permanent loss of vision, stop taking SILDENAFIL and call your doctor.

In case of chest pain occurring during or after sexual activity you should not use nitrates, but you should seek immediate medical assistance. Sudden decrease or loss of hearing has been reported in a few number of post-marketing and clinical trial cases with the use of PDE5 inhibitors, including sildenafil citrate. It has not been established whether these are related directly to the use of these medications or to other factors. If you experience these symptoms, stop taking SILDENAFIL and call your doctor.

Drugs that may interact with SILDENAFIL include:

  • any drugs that contain nitrates in any form (oral, sublingual [under the tongue], skin patch or by inhalation [spray]). Nitrates are found in many prescriptions that are used to treat angina pectoris (Chest pain due to heart disease). You should not take SILDENAFIL if you are taking these drugs.
  • alpha-blockers (drugs used to treat prostate problems or high blood pressure)
  • ketoconazole or itraconazole (drugs used to treat fungal infections)
  • erythromycin (a drug used to treat bacterial infections) ritonavir, saquinavir or other drugs for the treatment of HIV
  • cimetidine (a drug generally used to treat duodenal or gastric problems)

Grapefruit juice may increase the levels of SILDENAFIL in your blood.


As with most drugs, SILDENAFIL can cause some side effects. These effects are usually mild to moderate in nature and do not last for a long time.

The most common side effects are headache and facial flushing. Less commonly reported side effects are indigestion, dizziness, stuffy nose, effects on vision (including color tinge, increased brightness of light and blurred vision), seizure, seizure recurrence, sudden decrease or loss of hearing and transient global amnesia (temporary memory loss).

In extremely rare instances, a man may have an erection that lasts many hours. You should call a doctor immediately if you ever have an erection that lasts more than 4 hours.

Reports of sudden loss of vision have occurred rarely with the use of oral erectile dysfunction medications (PDE5 inhibitors). It has not been established whether these are related directly to the use of these medications or to other factors. There may be an increased risk to patients who have already experienced a condition called Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION). You should stop taking SILDENAFIL and consult your doctor if you experience a decrease in, or loss of, vision in one or both eyes.

Reports of serious skin reactions characterized by rash, blisters, peeling skin and pain, which require immediate medical attention, have also occurred rarely. You should stop taking SILDENAFIL and consult your doctor if you experience such reactions.

If you notice any side effects not mentioned above, or any of the above-mentioned side effects persist or become bothersome, please contact your doctor or pharmacist.

Source: Mint Pharmaceuticals Inc. Product Monograph

How does hCG affect my testosterone levels?

When hCG is administered, it stimulates the Leydig cells in the testes to produce more testosterone. This increase in testosterone production helps elevate circulating levels of the hormone in the bloodstream.

In some situations, men may experience low testosterone levels due to factors such as certain medical conditions, the use of anabolic steroids, or other reasons. hCG can be used to prevent or alleviate hypogonadism (insufficient testosterone production) by providing the necessary signals to the testes for increased testosterone synthesis.

Human Chorionic Gonadotropin –FAQs

Human Chorionic Gonadotropin (hCG) is a hormone that supports the normal development of an egg in a woman’s ovary and stimulates its release during ovulation. In men, it’s used to stimulate the testes to produce testosterone and is often utilized alongside Testosterone Replacement Therapy (TRT) to maintain fertility and testicular function.
In men, hCG mimics the action of Luteinizing Hormone (LH), which stimulates the Leydig cells in the testes to produce testosterone, a crucial hormone for sperm production. When used with TRT, hCG can help maintain or boost fertility by promoting sperm production, even as exogenous testosterone is being introduced to the body.
Men undergoing TRT who wish to maintain fertility or testicular function may qualify for hCG therapy. It’s crucial to be assessed comprehensively by a licensed medical practitioner who can determine if hCG is a suitable addition to your TRT regimen based on your medical history, current health status, and personal fertility goals.
The duration for which you need to take hCG will depend on your individual circumstances, such as your age, overall health, and fertility goals. It’s not typically a lifelong therapy, and Gambit’s licensed medical practitioners take into consideration your health, lab results, and fertility goals to make recommendations on the duration of your treatment.
If you stop taking hCG while on TRT, your body may cease producing its own testosterone and sperm, which might lead to reduced fertility and testicular atrophy over time. It’s important to discuss any changes in your treatment plan with your healthcare provider before making adjustments.
Gambit’s licensed health practitioners require bloodwork to be done in the morning, as that’s when testosterone levels are at their highest. However, additional requirements may vary based on the specific tests being conducted and Gambit’s licensed medical practitioners will provide specific instructions with each lab requisition.
The frequency of bloodwork will depend on the assessment by Gambit’s licensed medical practitioners, which can be influenced by your age, health status, and response to treatment. Initially, bloodwork will be required at 1-month and 2/2.5-months to monitor your response to the combination of TRT and hCG. Once a stable dosing regimen is established, Gambit’s licensed medical practitioners will determine the appropriate regular testing schedule for you.

Important Safety Information

Read More

– hCG help address hypogonadism

hCG is a natural, recombinant hormone that stimulates production of testosterone and sperm, both important for the potential fertility of men

– hCG improve testosterone deficiency

hCG are also sometimes used as an alternative to testosterone products in men with testosterone deficiency.

Testosterone along with hCG may help improve symptoms of testosterone deficiency while preventing some of testosterone’s side effects such as shrinking the gonads, altering sexual function and causing infertility.

– It improve sexual function

hCG may also improve sexual function as an androgen, either alone or in combination with a standard testosterone ester

– hCG reverse steroid side effects

hCG helps to prevent or reverse some of the side effects steroids cause, such as gonad shrinkage and infertility.